Spravato is a prescription nasal spray. It is used for treatment-resistant depression in adults. You will use it with an oral antidepressant, and a healthcare provider must supervise you during administration. Because you will receive your treatment at a certified center, this is not a medication you can take at home.
Preparing for Your Treatment Visits
Preparation helps your treatment go smoothly, so do not eat for at least two hours before your appointment. Avoid drinking liquids for 30 minutes before taking the medication. Because Spravato may cause sleepiness, arrange transportation home. Do not drive or operate machinery until the next day, after a full night’s sleep. Wear comfortable clothing for your visit. Plan to stay at the clinic for at least two hours after administration.
Bring a book, music, or another quiet activity for the observation period. Many people find it helpful to simply rest. Bringing a supportive friend or family member is comforting, because their presence may provide reassurance. Inform your doctor of any medications you are currently taking. Since some people feel anxious before treatment, this information can help your provider address your needs. This helps maintain safety and a smooth process. Plan meals and transport ahead of time, and reduce overall stress on treatment days.
What to Expect During Spravato
You will administer the nasal spray yourself, but a healthcare provider will show you how to use the device. Rest in a comfortable, reclined chair. You will tilt your head back slightly to use the spray. After using the spray, sniff gently to keep the medication inside your nose. Some people notice an unpleasant taste. A small candy or lozenge helps with this. You might feel the effects of the medication quickly. Remain seated for safety. Common side effects include dizziness or a feeling of disconnection. These feelings usually go away on their own within a couple of hours. The medical staff will monitor you closely and check your blood pressure and health signs. If you feel uneasy or have concerns at any point, tell the staff right away. They are there to support you and help keep you comfortable.
Next Steps and Monitoring Progress
Your doctor will check your progress after the first four weeks of treatment. This evaluation helps determine if the medication is working for you. If the treatment is effective, you will begin a maintenance phase with fewer visits. Your provider will adjust the schedule as needed. Keep taking your oral antidepressant as prescribed. Consistency supports the best results, and attending all scheduled appointments is a key part of the process. Keeping a journal of your moods and symptoms can be helpful. Share these notes with your doctor to support decisions about your care.
Schedule an Appointment
Plan your visits carefully. Spravato works differently from many standard antidepressants, so your healthcare provider will guide you through the steps. This treatment requires a time commitment. You will have frequent visits to the clinic in the first few weeks. If you have questions about Spravato, your team is here to help.